Protein name:
Ubiquitin carboxyl-terminal hydrolase 14 ;
Alternative:
Ubiquitin thiolesterase 14 ;Deubiquitinating enzyme 14 ;Ubiquitin-specific-processing protease 14 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1.
Function:
Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).
Subcellular Location:
Cytoplasm
Cell membrane
Peripheral membrane protein
Protein Attributes:
50:
MPLYSVTVKW | GKEKFEGVEL | NTDEPPMVFK | AQLFALTGVQ | PARQKVMVKG |
100:
GTLKDDDWGN | IKIKNGMTLL | MMGSADALPE | EPSAKTVFVE | DMTEEQLASA |
150:
MELPCGLTNL | GNTCYMNATV | QCIRSVPELK | DALKRYAGAL | RASGEMASAQ |
200:
YITAALRDLF | DSMDKTSSSI | PPIILLQFLH | MAFPQFAEKG | EQGQYLQQDA |
250:
NECWIQMMRV | LQQKLEAIED | DSVKETDSSS | ASAATPSKKK | SLIDQFFGVE |
300:
FETTMKCTES | EEEEVTKGKE | NQLQLSCFIN | QEVKYLFTGL | KLRLQEEITK |
350:
QSPTLQRNAL | YIKSSKISRL | PAYLTIQMVR | FFYKEKESVN | AKVLKDVKFP |
400:
LMLDMYELCT | PELQEKMVSF | RSKFKDLEDK | KVNQQPNTSD | KKSSPQKEVK |
450:
YEPFSFADDI | GSNNCGYYDL | QAVLTHQGRS | SSSGHYVSWV | KRKQDEWIKF |
494:
DDDKVSIVTP | EDILRLSGGG | DWHIAYVLLY | GPRRVEIMEE | ESEQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
Rabbit
ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 14
ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 14
ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 14
ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 14
CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 14
CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 14
CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 14
CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 14
Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 14
Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 14
Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 14
Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 14
Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 14
Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 14
Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 14
Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 14
Protein for Human Ubiquitin carboxyl-terminal hydrolase 14
Protein for Human Ubiquitin carboxyl-terminal hydrolase 14
Protein for Human Ubiquitin carboxyl-terminal hydrolase 14
Protein for Human Ubiquitin carboxyl-terminal hydrolase 14
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Placenta .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue :
Brain .
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Skin .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-308 (ISOFORM 2)
tissue :
T-cell .
7.
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FANCC
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
T-cell .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ASSOCIATION WITH THE 26S PROTEASOME;FUNCTION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH ERN1
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CXCR4;FUNCTION;SUBCELLULAR LOCATION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-449;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143 AND THR-235;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 91-494;CATALYTIC ACTIVITY;ACTIVE SITE